Bacteriocins are a family of antimicrobial peptide compounds of bacterial origin. As a matter of fact, some commensal bacteria can protect the host from other intruding species by producing and secreting bacteriocins. We like to consider them as special weapons bestowed by nature on helpful commensal species to defend against the attack of pathogens.
Lactococcus lactis MJC18
Lactoccous Lactis species has a long history of safe human use. Indeed, we exploit its acidification and preservation features in dairy industry applications. Specifically, strain MJC18 was carefully selected among others of the same species for its ability to produce a powerful bacteriocin: NISIN Z. This bacteriocin is one of the most important antimicrobial agents obtained from natural sources. It belongs to the family of Lantibiotics and acts by destroying the cells of its antagonistic bacteria by interfering during cell wall biosynthesis.
Our studies confirmed that LACTONOVA ZED can perform a strong antimicrobial activity against Gram-positive pathogens, such as Staphylococcus, Streptococcus, Clostridium and others.
Pediococcus acidilactici UL5
Pediococcus Acidilactici UL5 belongs to a robust species of probiotic bacteria that has excellent resistance to environmental stress as it can grow and adjust to a wide temperature, pH and osmotic pressure range. Moreover, this species has a long-standing history of safe human use. As a matter of fact, it is often employed for fermenting certain foodstuffs, such as milk or meat, and producing fermented vegetables, such as kimchi and pickle.
UL5 strain can produce PEDIOCIN PA-1, a class IIa bacteriocin with a broad action spectrum. The antimicrobial effect against harmful pathogens affecting the human GI-tract, such as Listeria monocytogenes and Clostridium difficile, makes this bacteriocin-producing strain the ideal candidate for targeted antimicrobial applications.
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