CARDIOnova

PROBIOTIC FOOD SUPPLEMENT FOR CARDIO-METABOLIC HEALTH

1 billion live probiotic “Bifido Q5 – the next generation of Bifidobacteria”

Reducose®

• Product Gluten & Lactose free – declared without food allergens
• Next generation Bifidobacterium psychraerophilum Q5 
• With Reducose® (white-mulberry leaves extract): patented-protected and clinically studied for support healthy blood sugar response
• Synergically combined with 1 billion live probiotic Bifido Q5 
• Unique combination investigated by Probionova with effectiveness data in a cardio-metabolic risk prevention

Scientific Data

Probiotics were investigated in an in vitro diabetic model, with regard to hyperglycemia, insulin resistance, hypercholesterolemia and dyslipidemias. In particular, the following were analyzed:

• analysis of cytotoxicity and production of reactive oxygen species
• the main markers involved in glucose metabolism (such as AKT, GLUT4 and PGC-1)
• cardiovascular risk analysis on endothelial and cardiac cell co-culture model

To better understand the effect, after the first screening the most effective combinations were studied in a complete cardio-metabolic model, including the intestinal passage up to the cardiovascular risk control:

• evaluation of liver damage
• analysis of free cholesterol levels
• lipids accumulation and circulating LDL
• inflammatory picture and pro-inflammatory cytokines analysis

Results

Metabolic syndrome and hypergliceamia are risk factors not only for diabetes but also for cardiovascular diseases. After assessing the probiotics in the diabetic model, we further investigated them for cardiovascular risk prevention. Here, Bifido Q5 showed by lead the most interesting properties when combined with white-mulberry leaves extract.

Indications

CARDIOnova is a probiotic food supplement dedicated for the cardio-metabolic control of hyperglycemia and pre-diabetes stages. The synergic combination of the probiotic Bifidobacterium psychraerophilum Q5 with the white mulberry leaves helps keeping under control all metabolic markers for cardiovascular risk. This unique combination has resulted in twice the effectiveness of the individual ingredients. Reducose® is a patented-protected and clinically studied white-mulberry leaves extract formulated to support healthy blood sugar response [clinical effective dosage: 200mg per serving]. Bifido Q5 is a next generation probiotic strain.

Ingredients

Carrier: maltodextrin; Reducose (white mulberry leaves extract); probiotics: B. psychraerophilum Q5; capsule casing: hydroxypropyl methylcellulose and gellan.