DIABnova

PROBIOTIC FOOD SUPPLEMENT FOR THE MANAGAMENT OF PRE-DIABETES CONDITION

THE NEXT GENERATION PROBIOTICS FOR THE METABOLIC-CONTROL

B. psychraerophilum Q5 + L. hordei KLL19 + L. harbinensis G8

• Product Gluten & Lactose free – declared without food allergens
• Synergically studied probiotic combination
• Next generation probiotics

Scientific Data

Probiotics were investigated in an in vitro diabetic model, with regard to hyperglycemia, insulin resistance, hypercholesterolemia and dyslipidemias. In particular, the following were analyzed:

• analysis of cytotoxicity and production of reactive oxygen species;
• quantification of glucose and insulin to analyze insulin resistance;
• the main markers involved in glucose metabolism (such as AKT, GLUT4 and PGC-1).

To better understand the effect, after the first screening the most effective combinations were studied in a complete metabolic model, including the intestinal passage up to the metabolic effect on the liver:

• evaluation of liver damage;
• analysis of free cholesterol levels;
• lipids accumulation and circulating LDL;
• cholesterol biosynthesis and metabolism (AMPK, PCSK9, SREBP2 and LDLr);
• hepatic metabolism, focusing on the main isoforms of CYP450;
• inflammatory picture and pro-inflammatory cytokines analysis.

Results

The combination of the three next generation probiotics showed an amplified positive effect (p<0.05) on intestinal and hepatic metabolism. Remarkably, the combo resulted to significantly (p<0.05 vs control) reduce the lipid accumulation.

Indications

Gluten-free, Lactose-free

DIABnova is a probiotic food supplement dedicated for the metabolic control of hyperglycemia and pre-diabetes stages. The synergic combination of three next generation probiotics strains has been investigated in an in vitro diabetic model, with regard to hyperglycemia, insulin resistance, hypercholesterolemia and dyslipidemias. The results showed the improvement of all markers assessed.

Ingredients

Carrier: maltodextrin; probiotics: L. hordei KLL19, B. psychraerophilum Q5, L. harbinensis G8; capsule casing: hydroxypropyl methylcellulose and gellan.