KIROnova

PROBIOTIC FOOD SUPPLEMENT TO SUPPORT YOUR REPRODUCTIVE HEALTH

1 billion live probiotics + D-chiro inositol and folic acid

• Product Gluten & Lactose free – declared without food allergens
• Vegan formula, available also as clean-label
• With L-methylfolate the natural and more bioactive form of folic acid
• Ingredients synergically combined with 1 billion live probiotics
• Label registered; Free-sale certificate available

Authorized health claim: “FOLATE CONTRIBUTES TO MATERNAL TISSUE GROWTH DURING PREGNANCY”

Product Indication

DCI stimulates insulin function in managing blood glucose and lipids within normal levels. Thanks to its effect, it reduces circulating insulin, decreases serum androgens and improves conditions related to excess weight, thus promoting an improvement in ovulation. Folic acid is essential for cell growth and multiplication. It is involved in correct bio-synthesis of DNA, proteins and for the formation of hemoglobin.

Scientific Data

Probiotics with evidences for guarantee the balance of the vaginal microbiota have been studied for more specific applications in the field of female fertility. Through an in vitro model of myometrium, the following parameters were analyzed:

• Cytotoxicity and ROS production
• Analysis of the cell cycle and cell proliferation
• Stimulation of ovarian cells metabolism and functionalities
• Quantification of oxytocin
• Analysis of contractile activity
• Analysis of FSH and LH production
• Analysis of biomarkers involved in apoptotic processes
• Analysis of the main markers involved in the pathogenesis of PCOS (FGD4, CDC42 and PAK1)

Results

Only the combination of Lactobacillus crispatus, Lactobacillus fermentum and Bifidobacterium bifidum showed an amplified positive effect (p<0.05) on intestinal and ovarian metabolism compared to single strains. Remarkably, the combo of such probiotics resulted able to significantly (p<0.05 vs control) promote the mitochondrial metabolism of ovarian cells.

Indications

KIROnova is a probiotic food supplement specially designed to provide a synergic combination of nutrients for an effective approach against PCOS symptoms and for the prevention myometrial trophism.  DCI stimulates insulin function in managing blood glucose and lipids within normal levels. Thanks to its effect, it reduces circulating insulin, decreases serum androgens and improves conditions related to excess weight, thus promoting an improvement in ovulation. Folic acid is essential for cell growth and multiplication. It is involved in correct bio-synthesis of DNA, proteins and for the formation of hemoglobin. L. crispatus novaLCR6 is the main dominant lactobacilli present in the vaginal environment of healthy women. Its presence correlates with healthy and successful reproductive outcomes.

Ingredients

D-chiro-inositol; carrier: maltodextrin; probiotics: L. crispatus novaLCR6 (DSM 34348); capsule casing: hydroxypropyl methylcellulose and gellan; L-methylfoalte.