PROBIOTIC COMBINATION TO SUPPORT THE MOOD & COGNITIVE FUNCTIONALITY OVER THE GUT-BRAIN AXIS
L. paracasei TJB8 (DSM 33129)
B. bifidum novaBBF7 (DSM 34336) B. longum novaBLG2 (DSM 34339)
Recommended dosage: 4.5 billion cells per day
Scientific Data
The selected probiotics have been studied to evaluate their effect on the modulation of the gut-brain axis. The model used is valid for in vitro studies on depression and anxiety and allows to evaluate:
- Cytotoxicity and cell-protection against oxidative damages
- Inflammatory picture
- Biomarkers for anxiety
- Biomarkers for neurodegeneration
- Interleukins involved in anxiety and depression
- Analysis of apoptotic activity
- Analysis of the production of neurotrophic factors
- Analysis of the expression of proteins implicated in brain plasticity • Analysis of membrane potential and mitochondrial metabolism
- Quantification of glutamate, homocysteine and serotonin levels
The combination of B. bifidum, B. longum and L. paracasei was the one achieving the best cumulative scores in all the model compartments. The probiotics combo is able to exert a greater effect on the Gut-Brain model compared to other tested agents (p<0.05), thus resulting in better support for mood regulation and having a greater influence on neuronal environment.
PROBIOTICS COMBO EFFECT VARIATION VS REFERENCE
Key Points
- Exclusive synergic probiotic combination
- Studied in a pre-clinical in vitro human model of gut-brain axis, shown to be effective in:
- Improving biomarkers related to depressive states and mood disorders
- Maintaining the normal cognitive activity during aging
- Scientific paper and communication will be submitted shortly to peer-re- viewed journals (IF >5)
- Patented probiotic strains and patent application for the unique combina- tion
- Clinical trial protocol submitted to ethical committee for trial approval and starts in 2023
- Without food allergens Reg. 1169/2011
- Available as premix, standardized at 180 billion
